Translational Research Lead Fibrosis - Mechelen,BE/Basel,CH/Romainville,FR/Leiden,NL

Job description

Pleased to meet you, we are Galapagos, a dynamic fast growing Biotech company with offices in Europe in Belgium (Mechelen), France (Romainville & Paris), the Netherlands (Leiden), Switzerland (Basel), Italy (Milano), Spain (Madrid), the UK (London), Germany (München), and in the US (Boston).

 

We’re in the business of changing lives. In our quest to discover and develop life-improving medicines we go where no one has ever gone before. In every challenge we face, we see new opportunities. We want to challenge the impossible. We need thought leaders and rapid thinkers, entrepreneurs in spirit and status quo-fighters. Collaborative innovators and perseverant idealists. We need the best-in-class. In other words, we need you: The ‘make-it-happeners’.

 

We are looking for a Translational Research Lead Fibrosis - Mechelen,BE/Basel,CH/Romainville,FR/Leiden,NL


You have a key role at the interface between Discovery and Development Departments. At one hand, you lead the Translational Research activities for new therapeutic molecules in Development phases (from Preclinical stage on) to strengthen the translation of data from preclinical models to human, drive indication selection (forward translation), refine the understanding of potential safety risks and design the biomarker strategy. At the other hand, you are responsible for Translational Research activities aiming at generating new mechanistic insights for the different diseases Galapagos is focusing on. These back-translation activities are based on diverse types ‘omics’ data generated from diseased tissue collected in clinical trials. 

These new mechanistic insights will represent the basis for the selection of innovative pathways and targets for drug discovery. Expert advisor to the Head of Fibrosis Disease Area, you play a central role in the success of strategies for molecules progressed in clinical trials as well as in setting the basis for future drug discovery efforts. Finally, the Translational Research Lead is actively contributing to the generation of an up-to-date knowledge environment for fibrotic diseases and to set up and drive external academic collaborations to generate Translational data related to development molecules or fibrotic diseases.

Principal Accountabilities:

  • Acts at the interphase between Discovery and Development divisions, driving continued translational activities for projects in Development phases,
  • Translating clinical data into actionable insights in disease mechanisms that will impact the path of existing clinical molecules but also drive the strategy selected for the future drug discovery efforts,
  • At one hand, the Translational Research Lead will be responsible for establishing a strategy to map disease mechanisms:
    • develop and implement strategies for the collection / generation of disease-related data from the clinic.
    • integrate molecular (e.g. 'omics') data, ultimately also with disease-related outcome measures or patient reported outcomes.
    • build and experimentally confirm / infirm mechanistic hypotheses within Galapagos' core disease areas.
    • consolidate and integrate mechanistic insights onto disease networks.
    • ultimately define the next mechanisms / pathways to be targeted in Research to address the patient's unmet needs.
  • At the other hand, the Translational Research Lead will be responsible for building in depth understanding of the biology of GLPG's clinical compounds:
    • develop strategies for the collection / generation of data relevant to the action of Galapagos' molecules in human.
    • drive the target biomarker strategy.
    • drive as required the selection of disease biomarkers in close interaction with the Clinical Research team.
    • integrate datasets obtained for Galapagos molecules (pre-clinical and clinical) to position the level of efficacy versus competition.
    • input in patient stratification strategies.
    • ultimately do evidence-based proposals of alternative indications for advanced Galapagos molecules.
  • Managing external scientific collaborations.



Job requirements

Who are you?

  • Ph.D. with at least 8 years drug discovery experience.
  • Scientific expertise in Fibrosis as well as an understanding of the competitive landscape in the area.
  • Knowledge of the drug discovery process supported by a demonstrated track record of delivery and leadership in drug discovery projects.
  • Solid knowledge of in vitro and in vivo pharmacology as well as of concepts in pharmacokinetics.
  • Knowledge of Translational concepts. An affinity with state-of-the art ‘omics’ technologies is an advantage.
  • Excellent proven leadership skills, with the ability to influence, motivate and empower.
  • With a strategic view, you are able to act as an advisor and influencer of top management and the teams.
  • Creative and critical thinker. Able to build a synthetic view on literature in the field.

What’s in it for you ?

You will be part of a fast growing and amazing company. As ‘make-it-happener’ you will get all the support you need to make your job successful. At Galapagos we aim to recruit the best people, who stand out among their peers, with integrity and excellent interpersonal and organizational skills. Our employees are the strength behind Galapagos, a highly motivated team, eager to maintain Galapagos’ leading position and achieve breakthroughs in pharmaceutical research. Galapagos offers a competitive remuneration package and a dynamic work environment.

 

We are Galapagos: together we can make it happen…!