Translational Research Lead Fibrosis - Basel,CH

Job description

Pleased to meet you, we are Galapagos, a dynamic fast growing Biotech company with offices in Europe in Belgium (Mechelen), France (Romainville & Paris), the Netherlands (Leiden), Switzerland (Basel), Italy (Milano), Spain (Madrid), the UK (London), Germany (München), and in the US (Boston).

 

We’re in the business of changing lives. In our quest to discover and develop life-improving medicines we go where no one has ever gone before. In every challenge we face, we see new opportunities. We want to challenge the impossible. We need thought leaders and rapid thinkers, entrepreneurs in spirit and status quo-fighters. Collaborative innovators and perseverant idealists. We need the best-in-class. In other words, we need you: The ‘make-it-happeners’.

 

We are looking for a Translational Research Lead Fibrosis - Basel,CH


 In the area of fibrotic diseases, the Translational Research Lead plays a central role at the interface between the discovery and development departments.

To achieve your goals, you will have a central position amongst various stakeholders. At one hand, you are interacting with other members of the Disease Biology group, including the Disease Area Heads as well as the other Pharmacology Leaders. In addition, you are operating in a matrix environment and orchestrates the activities of several departments in the discovery organization, ranging from in vitro through in vivo pharmacology as well as translational science and bioinformatics. The Translational Research Lead activities are performed in close collaboration with the Translational Medicine department. You are  also operating outside Galapagos, designing and driving external academic collaborations with experts in the field.


You will be responsible for…

  • Driving late stage projects as Pharmacology Leader in the project team for projects in Development. Typically, the Pharmacology Leader is responsible for designing the pharmacology plans and interpreting (pre-)clinical data (e.g. biomarker data) for a development project, aiming at understanding the efficacy level and mechanism of action of the compound in a given disease compared to competitor molecules as well as selecting alternative indications. In addition, the Translational Research Lead plays a central role in the selection of biomarker strategies in coordination with the biomarker leaders.
  • At the other hand, the Translational Research Lead will be responsible for establishing strategies for back translation:
    • To develop and implement strategies to collect/generate disease-related data from the clinic and bring those evidences back to research.
    • To integrate molecular (e.g. ‘omics’) data, ultimately also with disease-related outcome measures or patient reported outcomes.
    • To build and experimentally confirm/infirm mechanistic hypotheses within Galapagos’ core disease areas.
    • To consolidate and integrate mechanistic insights onto disease networks.
    • Ultimately define the next approaches and pathways to be targeted in Research to address the patient’s unmet needs.

Responsibilities

  • Integrating knowledge on pathogenic pathways and competitor molecules gathered from internal / external datasets, key literature, feedback of KOL’s, congresses.
  • Functionally mapping the competitive environment for Galapagos’ advanced molecules.
  • Bring key elements guiding the design of competitive strategies for selected diseases.
  • Leading Pharmacology activities for the characterization of molecules in Development phases, with emphasis on Translational activities.
  • Efficient reporting on progress to the scientific management team of the company.
  • Building a productive and trust-based collaboration with the Galapagos expert teams.
  • Managing external scientific collaborations.
  • Assist the Business Development team by providing critical reviews of potential external assets.

    Job requirements

    Who are you?

    • Ph.D. with at least 6-10 years drug discovery experience in the biotech or pharmaceutical industry.
    • Knowledge of the drug discovery process supported by a demonstrated record of accomplishment of delivery and leadership in drug discovery projects.
    • Solid knowledge of in vitro and in vivo pharmacology as well as of concepts in pharmacokinetics.
    • Demonstrated capability to interpret complex (e.g. ‘omics-type’) datasets.
    • Knowledge of translational concepts (use of target and disease biomarkers).
    • In depth understanding of processes driving disease in inflammation, autoimmunity or fibrosis is key, as well as an understanding of the competitive landscape in the area.
    • Excellent communication and interpersonal skills.
    • Talented in organizing and planning.
    • Creative and critical thinker. Able to build a synthetic view in the field.
    • Experience in working in a matrix environment represents an advantage.

    What’s in it for you ?

    You will be part of a fast growing and amazing company. As ‘make-it-happener’ you will get all the support you need to make your job successful. At Galapagos we aim to recruit the best people, who stand out among their peers, with integrity and excellent interpersonal and organizational skills. Our employees are the strength behind Galapagos, a highly motivated team, eager to maintain Galapagos’ leading position and achieve breakthroughs in pharmaceutical research. Galapagos offers a competitive remuneration package and a dynamic work environment.

     

    We are Galapagos: together we can make it happen…!