Team Leader Computational Chemistry - Mechelen,BE/Romainville,FR

Job description

Pleased to meet you, we are Galapagos, a dynamic fast growing Biotech company with offices in Europe in Belgium (Mechelen), France (Romainville and Paris), the Netherlands (Leiden), Basel (Switzerland), Spain (Madrid), Italy (Milan) and in the US, (Boston).

We’re in the business of changing lives. In our quest to discover and develop life-improving medicines we go where no one has ever gone before. In every challenge we face, we see new opportunities. We want to challenge the impossible. We need thought leaders and rapid thinkers, entrepreneurs in spirit and status quo-fighters. Collaborative innovators and perseverant idealists. We need the best-in-class. In other words, we need you : The ‘make-it-happeners’.

 

We are looking for a Team Leader Computational Chemistry  - Mechelen,BE or Romainville, FR

 

As Team Leader for the "Molecular Modelling & Design" team, you will be responsible for the judicious application of computational methods to the discovery and optimization of drug candidates. You will provide scientific contributions to drug discovery projects yourself and supervise 3 other team members in this endeavor.

You will be involved in structure-based (SB) and ligand-based (LB) drug design, compound selection and acquisition, HTS data analysis and triage, virtual screening, statistical modelling, and ADMET prediction. You will be working closely with medicinal chemists, biologists, DMPK scientists and other project team members to define and achieve project goals.

As part of the larger Computational Research group (10 people), you will also have the opportunity to participate in evaluating, developing, implementing and applying new computational methodologies and strategies. You will identify areas of scientific improvement within computational sciences and their potential for application to projects. You will contribute to the development of new computational capabilities and maintain an up-to-date awareness of recent literature and current developments within the field.

You will be located either on the Mechelen (Belgium, Brussels area) or Romainville (France, Paris area) site, to your convenience.

Job requirements

Who are you?

  • A Ph.D. degree with a demonstrated track record in computer-aided support to drug discovery projects. Experience in an industrial setting would be an advantage.
  • Expertise in structure- and ligand-based drug design, with strong experience in common molecular modelling techniques (protein homology modelling, docking, pharmacophore modelling, target- and ligand-based virtual screening)
  • Expertise in at least one of the following techniques would be a plus: ADMET and physicochemical property prediction, machine learning, molecular simulations (MD), FEP, quantum mechanics calculations
  •  A good background in organic chemistry
  • Programming, scripting (Python), and good knowledge of Linux
  • Experience with data-workflow tools (such as Pipeline Pilot or Knime)
  • Knowledge of drug target families (kinases, GPCRs, proteases, PDEs)
  • Experience in managing teams in an international context
  • Fluent in English, preferably also in Dutch and/or French

You will be part of a fast growing and amazing company. As a “make-it-happener” you will get all the support you need to make your job successful. At Galapagos we aim to recruit the best people, who stand out among their peers, with integrity and excellent interpersonal and organizational skills. Our employees are the strength behind Galapagos, a highly motivated team, eager to maintain Galapagos’ leading position and achieve breakthroughs in pharmaceutical research. Galapagos offers a competitive remuneration package and a dynamic work environment.

 

We are Galapagos: together we can make it happen...!