Senior Scientist Protein Production and Purification - Romainville,FR

Job description

Pleased to meet you, we are Galapagos, a dynamic fast growing Biotech company with offices in Europe in Belgium (Mechelen), France (Romainville & Paris), the Netherlands (Leiden), Switzerland (Basel), Italy (Milano), Spain (Madrid), the UK (London), Germany (München), and in the US (Boston).

We’re in the business of changing lives. In our quest to discover and develop life-improving medicines we go where no one has ever gone before. In every challenge we face, we see new opportunities. We want to challenge the impossible. We need thought leaders and rapid thinkers, entrepreneurs in spirit and status quo-fighters. Collaborative innovators and perseverant idealists. We need the best-in-class. In other words, we need you: The ‘make-it-happeners’.


We are looking for a Senior Scientist Protein Production and Purification - Romainville,FR 


The Protein Sciences department supports Galapagos’ drug discovery programs by providing high quality protein tools for HTS campaigns, in vitro assay development, small-molecule biophysical characterization (crystallography, NMR, SPR, MST...) and antibody identification. Within the team, a diverse set of expertise and technologies are present in the fields of molecular biology, cell biology, protein purification, biophysical and structural protein characterization.


Scope of the job

You will be in charge of the production, purification and characterization of recombinant proteins used for internal drug discovery programs. You will combine a strong knowledge and hands-on experience in protein biochemistry and purification with the ability to work in a team-oriented, results-driven and multi-disciplinary environment. You should have a strong desire to continue in a laboratory-focused role (70% bench work).


Your responsibilities 

  • Preparation and characterization of research-grade proteins at mg scale levels
  • Drive the implementation of robust and efficient purification strategies for new protein targets and execute the experiments
  • Closely interact with colleagues responsible for the upstream and downstream activities to streamline the workflow
  • Provide critical analysis of the generated data and if needed propose alternatives to ensure delivery of proteins with sufficient quality and quantity for further research work
  • Evaluate and implement internal and external cutting-edge protein purification methods
  • Coach and supervise student(s), technician(s), scientist(s) and associate(s), and foster develop, manage and motivate one or more team member
  • Contribute to the selection of CROs and collaborations to support Protein Sciences activities
  • Represent the Protein Sciences team in project team meetings and clearly report generated data to maximize the scientific input
  • Gather project team requests in terms of Protein Sciences activities and ensure fast communication to the team
  • Write scientific reports and contribute to scientific publications, patent authorship and grant or project proposals


Job requirements

Who are you?

  • PhD degree with 4-6 years’ experience in applicable field (biochemistry, molecular and structural biology, etc.) or a Master/Engineer degree with 8 plus years’ experience in Biochemistry and Protein Purification
  • Thorough knowledge and hands-on experience with the different chromatography techniques used for protein purification (affinity, ion exchange, size exclusion,…) as well as Akta systems
  • Experience with methods for protein quality assessment (SDS-PAGE, Western Blot, NanoDSF, …)
  • Good understanding of molecular biology, recombinant protein expression and protein biophysical characterization
  • High attention to detail and critical mindset when looking at scientific data, both from internal and external sources
  • Careful documentation of results in lab notebooks

What's in it for you?

You will be part of a fast growing and amazing company. As ‘make-it-happener’ you will get all the support you need to make your job successful. At Galapagos we aim to recruit the best people, who stand out among their peers, with integrity and excellent interpersonal and organizational skills. Our employees are the strength behind Galapagos, a highly motivated team, eager to maintain Galapagos’ leading position and achieve breakthroughs in pharmaceutical research. Galapagos offers a competitive remuneration package and a dynamic work environment.


We are Galapagos: together we can make it happen…!