Senior (Principal) Molecular Modeler / Computational Chemist - Mechelen,BE

Job description

Pleased to meet you, we are Galapagos, a dynamic fast growing biotech company with offices in Europe, in Belgium (Mechelen), France (Romainville), the Netherlands (Leiden), Switzerland (Basel) and in the US (Boston).


We’re in the business of changing lives. In our quest to discover and develop life-improving medicines we go where no one has ever gone before. In every challenge we face, we see new opportunities. We want to challenge the impossible. We need thought leaders and rapid thinkers, entrepreneurs in spirit and status quo-fighters. Collaborative innovators and perseverant idealists, we need the best-in-class. In other words, we need you: The ‘make-it-happeners’.


We are looking for a Senior/Principal Molecular Modeler (Computational Chemist) - Mechelen,BE


Scope of the job

As member of the Molecular Modelling & Design team (part of the Computational Research group, 8 people), your primary responsibility will be the judicious application of computational methods to the discovery and optimization of drug candidates.

You will be involved in structure-based (SB) and ligand-based (LB) drug design, compound selection and acquisition, HTS data analysis and triage, virtual screening, statistical modelling, and ADMET prediction. You will be working closely with medicinal chemists, biologists, DMPK scientists and other project team members to define and achieve project goals.

You will also have the opportunity to participate in evaluating, developing, implementing and applying new computational methodologies and strategies. You will identify areas of scientific improvement within computational sciences and their potential for application to projects. You will contribute to the development of new computational capabilities and maintain an up to date awareness of recent literature and current developments within the field.


Job requirements

 Who are you?

  • A Ph.D. degree followed by at least 3 years of experience in computer-aided support to drug discovery projects in a multi-disciplinary project team. Experience in an industrial setting would be an advantage.
  • Expertise in structure- and ligand-based drug design
  • A good background in organic chemistry and a solid knowledge of medicinal chemistry concepts
  • Required skills:
    • Programming, scripting and/or query languages (such as Python, SQL)
    • Good knowledge of Linux and awareness of the latest hardware and cloud solutions
    • Knowledge of drug target families (kinases, GPCRs, proteases, PDEs)
    • Strong experience in common molecular modelling techniques (protein homology modelling, docking, pharmacophore modelling, target- and ligand-based virtual screening)
    • Strong expertise in at least one of the following techniques: ADMET and physicochemical property prediction, machine learning, molecular simulations (MD), FEP, quantum mechanics calculations
    • Experience with data-workflow tools (such as Pipeline Pilot or Knime)

What’s in it for you?

You will be part of a fast growing and amazing company. You will get all the support you need to make your job successful. At Galapagos we aim to recruit the best people, who stand out among their peers, with integrity and excellent interpersonal and organizational skills. Our employees are the strength behind Galapagos, a highly motivated team, eager to maintain Galapagos’ leading position and achieve breakthroughs in pharmaceutical research. Galapagos offers a competitive remuneration package and a dynamic work environment.

We are Galapagos: together we can make it happen…!