Molecular Modeler / Computational Chemist - Romainville, FR

Job description

 

 

Pleased to meet you, we are Galapagos, a dynamic fast growing biotech company with offices in Europe, in Belgium (Mechelen), France (Romainville), the Netherlands (Leiden), Switzerland (Basel) and in the US (Boston).

 

We’re in the business of changing lives. In our quest to discover and develop life-improving medicines we go where no one has ever gone before. In every challenge we face, we see new opportunities. We want to challenge the impossible. We need thought leaders and rapid thinkers, entrepreneurs in spirit and status quo-fighters. Collaborative innovators and perseverant idealists, we need the best-in-class. In other words, we need you: The ‘make-it-happeners’.

 

For our site in Romainville, France we are looking for a Molecular Modeler / Computational Chemist

 

Scope of the job

Preferred location is Romainville (Paris area, France) but working on the Mechelen site (Brussels area, Belgium) can also be an option.

As member of the Molecular Modelling & Design team, your primary responsibility will be the judicious application of computational methods to the discovery, optimization, and development of drug candidates.

 

Your role

  • You will be involved in structure-based (SB) and ligand-based (LB) drug design, compound selection and acquisition, HTS data analysis and triage, virtual screening, statistical modelling, and ADMET prediction.
  • You will be working closely with medicinal chemists, biologists, DMPK scientists and other project team members to define and achieve project goals.
  • You will also have the opportunity to participate in evaluating, developing, implementing and applying new computational methodologies and strategies.

 

 

Requirements

 

Who are you?

  • A Ph.D. degree or equivalent with a demonstrated track record in computer-aided drug discovery is required.
  • Expertise in structure- and ligand-based drug design is essential.
  • Basic knowledge of organic chemistry is a must.
  • Experience with data-workflow tools (such as Pipeline Pilot) and programming, scripting and/or query languages (such as Python, SQL) is an asset.
  • Knowledge of drug target families (kinases, GPCRs, proteases, PDEs), ADMET and physicochemical property prediction, statistics, machine learning, HTS data analysis and triage, protein homology modelling, molecular simulations, FEP, and quantum mechanics calculations would be an advantage.
  • Good knowledge of Linux and awareness of the latest hardware and cloud solutions would be a plus.
  • Self-motivation, eagerness to learn and good communication skills are essential.

Do you have the qualifications for this job opening, and are you up to the challenge of joining our dynamic and entrepreneurial team?

 

What’s in it for you?

You will be part of a fast growing and amazing company. You will get all the support you need to make your job successful. At Galapagos we aim to recruit the best people, who stand out among their peers, with integrity and excellent interpersonal and organizational skills. Our employees are the strength behind Galapagos, a highly motivated team, eager to maintain Galapagos’ leading position and achieve breakthroughs in pharmaceutical research. Galapagos offers a competitive remuneration package and a dynamic work environment.

We are Galapagos: together we can make it happen…!