Associate Pharmacometrican PBPK - Romainville, FR

Job description

 

Pleased to meet you, we are Galapagos, a dynamic fast growing Biotech company with offices in Europe in Belgium (Mechelen), France (Romainville), the Netherlands (Leiden) and in US, Boston.

We’re in the business of changing lives. In our quest to discover and develop life-improving medicines we go where no one has ever gone before. In every challenge we face, we see new opportunities. We want to challenge the impossible. We need thought leaders and rapid thinkers, entrepreneurs in spirit and status quo-fighters. Collaborative innovators and perseverant idealists. We need the best-in-class. In other words, we need you: The ‘make-it-happeners’.

 

For our site in Romainville, France (or alternatively Leiden, Netherlands) we are looking for a Pharmacometrician

 

Scope of the job

Within the Clinical Pharmacology department, you will apply quantitative approaches to understand the pharmacokinetics of novel compounds and to inform the design of clinical pharmacology studies. The focus is on extrapolation from animal to human, drug-drug interaction, and formulation development (IVIVc).

 

Your role

  • Manage and apply PBPK and population PK modelling in close collaboration with the Clinical Pharmacology leaders, Pharmacometrics experts, and external partners
  • Help maintaining and improving the PBPK workflow with focus on traceability and documentation
  • Contribute to pharmacometric reports and presentations for internal decision making and interaction with regulatory agencies
  • Communicate results of the analyses to project teams (Clinical Development Team or Project Team)
  • You will report to the Head of Pharmacometrics.

 

Job requirements

Who are you?
 

  • PhD or MSc in quantitative pharmacology, applied mathematics, or related field with a special focus on (population) pharmacokinetics and PBPK modelling.
  • At least 3 years of experience in Preclinical (DMPK) or Clinical Development in Pharmaceutical Industry, Contract Research Organizations or academia, of which some years applying PBPK modelling.
  • Hands-on experience with PBPK software, such as PKSIM/MOBI, SimCyp, and Gastroplus. Proficiency in R, Matlab, Python or similar programming language is required.
  • Experience with one or more population modelling software (Monolix, NONMEM or similar) as well as the concept of “Model informed Drug Discovery and Development is desirable”.
  • You know how to work independently and within a team and to set priorities when working on several projects simultaneously.
  • Excellent written and oral communication in English.

 

What’s in it for you ?

You will be part of a fast growing and amazing company. As ‘make-it-happener’ you will get all the support you need to make your job successful. At Galapagos we aim to recruit the best people, who stand out among their peers, with integrity and excellent interpersonal and organizational skills. Our employees are the strength behind Galapagos, a highly motivated team, eager to maintain Galapagos’ leading position and achieve breakthroughs in pharmaceutical research. Galapagos offers a competitive remuneration package and a dynamic work environment.

We are Galapagos : together we can make it happen…!