Intern Process Research Chemistry (Scale-up), Romainville, FR

Job description

Pleased to meet you, we are Galapagos, a dynamic fast growing Biotech company with offices in Europe in Belgium (Mechelen), France (Romainville), the Netherlands (Leiden) and in US, Boston.

 

We’re in the business of changing lives. In our quest to discover and develop life-improving medicines we go where no one has ever gone before.   In every challenge we face, we see new opportunities.  We want to challenge the impossible.  We need thought leaders and rapid thinkers, entrepreneurs in spirit and status quo-fighters.  Collaborative innovators and perseverant idealists. We need the best-in-class.  In other words, we need you : The ‘make-it-happeners’. 

 

We are looking for an Intern in Process Research Chemistry - Scale up

 

 (4-6 months starting between February and Early May 2019 – M/F)

                                               

Scope of the job

 The Scale-up department is part of the Galapagos development organization and is based at Romainville (France). The missions of the team are to develop and improve synthetic routes on small scale towards Active Pharmaceutical Ingredient (API) and to manufacture 500g to 1kg of API. The scale-up team activities are mainly focused on organic chemistry, optimizing reactions, using the latest technologies to prepare and characterize compounds.    

 

Your role 

  • You will participate to the identification of suitable synthetic routes on small scale (100mg or less)
  • You will perform analysis to monitor reaction progress (HPLC, TLC) and characterize final products (HPLC, NMR…)
  • Following identification of a suitable route, you will adapt it to prepare intermediates on larger scale (10-50g) therefore acquiring specific knowledge on upscaling reactions.
  • As a secondary mission (1-2 week time), you will update an advanced database dedicated to solvents. The solvent database is providing recommendations/suggestions to the chemists on which solvents should be tested during the optimization of a reaction.
  • As part of the chemistry department of Galapagos, you will also interact with colleagues from the Medicinal chemistry and the Analytical departments. As an example, you will present your work during dedicated chemistry meetings.

Requirements

Who are you ?

 You are currently in Master 2 or in an Engineering School. You are interested by organic chemistry, and willing to apply your knowledge to solve chemistry problems. You show good organisation skills and are a team player.

 

What’s in it for you ?

 You will be part of a fast growing and amazing company.  As ‘make-it-happener’ you will get all the support you need to make your job successful.  At Galapagos we aim to recruit the best people, who stand out among their peers, with integrity and excellent interpersonal and organizational skills. Our employees are the strength behind Galapagos, a highly motivated team, eager to maintain Galapagos’ leading position and achieve breakthroughs in pharmaceutical research. Galapagos offers a dynamic work environment.

 

We are Galapagos: together we can make it happen…!